Forskolin reference

The herb Coleus forskohlii is used by the Hindu traditional medicine to treat asthma, heart disease and more. The small mint-family herb is also found in Sri Lanka, Thailand, and Nepal. In the 1970s, a chemically active ingredient called Forskolin was isolated from the herb . Forskolin is commonly used for treating hypothyroidism.
Specifically, forskolin is believed to increase thyroid function by activating cAMP (cyclic adenosine monophosphate).

http://www.wholehealthmd.com/refshelf /substances_view/1,1525,10025,00.html#What_Is_It

Forskolin and glaucoma: forskolin has been reported to reduce sometimes the intraocular pressure. This may be related to its ability to stimulate adenylate cyclase activity and increase cyclic adenosine monophosphate (cAMP) which regulates and activates critical enzymes required for the cellular energy required to move fluid out of the eye http://www.lef.org/prod_desc/item00300.html

To date, there have been two clinical studies examining the effectiveness of forskolin as a weight loss aid. Neither have yet been subject to peer-review or published in a medical journal. Additionally, according to the company that manufactures and administers the patented form of forskolin, two more clinical studies are being sponsored. Research update, www.npicenter.com June 2001.

View molecule using rasmol:

* The diterpene forskolin was isolated for its pronounced biological activities.

the 10 selected Forskolin abstracts

1	Effects of sex hormones, forskolin, and nicotine on choline acetyltransferase activity in human isolated placenta.
2	Effects of sex hormones, forskolin, and nicotine on choline acetyltransferase activity in human isolated placenta.
3	The tyrosine kinase inhibitor genistein increases basal cAMP and potentiates forskolin-induced cAMP accumulation in A549 human airway epithelial cells.
4	Cardiovascular and adenylate cyclase stimulating effects of colforsin daropate, a water-soluble forskolin derivative, compared with those of isoproterenol, dopamine and dobutamine.
5	Forskolin-Induced Clearance of the Fluorescent Dye Sulforhodamine from Rat Parotid Intralobular Duct Lumen: Visualization of the Secretory Function under a Confocal Laser Scanning Microscope.
6	Identification of a truncated dual oxidase 2 (DUOX2) messenger ribonucleic acid (mRNA) in two rat thyroid cell lines. Insulin and forskolin regulation of DUOX2 mRNA levels in FRTL-5 cells and porcine thyrocytes
7	Intravitreal injections of neurotrophic factors and forskolin enhance survival and axonal regeneration of axotomized beta ganglion cells in cat retina.
8	Bacterial lipopolysaccharide-stimulated release of tumor necrosis factor-alpha from the isolated rat heart: the effect of aprotinin and forskolin.
9	Increased relaxant action of forskolin and isoproterenol against muscarinic agonist-induced contractions in smooth muscle from M2 receptor knockout mice.
10	Effects of sex hormones, forskolin, and nicotine on choline acetyltransferase activity in human isolated placenta.

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4mg noneto biocompare formulae omd ToxicPlants DictCellBio MolBioDict ( test position ) BioChemical Suppliers

A23187	Actinomycin	Aflatoxin	Anisomycin	Aphidicolin	Ascomycin
Bleomycin	Brefeldin	Cerulenin	Chromomycin	Geldanamycin	Cyclopiazonic acid
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KT5823	Mitomycin	Nigericin	Ochratoxin	Oligomycin	Mycophenolic acid
Paclitaxel	Patulin	Paxilline	Penitrem	Puromycin	Penicillic acid
Radicicol	Rapamycin	Staurosporine	Sterigmatocystin	Thapsigargin	Tunicamycin
Verruculogen	Wortmannin