webhosting   Cheap Reseller Hosting   links    free hosting by fateback   hosting reseller   100WebSpace offers 100MB Web Space 
Free Links
Free Image Hosting, Web Hosting, Architectural Projects in Bulgaria, Famous People & Celebrity Search, Web Page Hosting


Forskolin

 
7: Circ J 2002 Dec;66(12):1150-4  
 
 

Cardiovascular and adenylate cyclase stimulating effects of colforsin daropate, a water-soluble forskolin derivative, compared with those of isoproterenol, dopamine and dobutamine.



Yoneyama M, Sugiyama A, Satoh Y, Takahara A, Nakamura Y, Hashimoto K.

Department of Pharmacology, Yamanashi Medical University, Tamaho-cho, Nakakoma-gun, Japan.

Colforsin daropate is a recently developed water-soluble derivative of forskolin that directly stimulates adenylate cyclase, unlike the catecholamines. The chronotropic, inotropic and coronary vasodilator actions of colforsin daropate were compared with those of isoproterenol, dopamine and dobutamine, using canine isolated, blood-perfused heart preparations. The stimulating effect of each drug on adenylate cyclase activity was also assessed. Colforsin daropate, as well as each of the catecholamines, exerted positive chronotropic, inotropic and coronary vasodilator actions. The order of selectivity for the cardiovascular variables of colforsin daropate was coronary vasodilation >> positive inotropy > positive chronotropy; whereas that of isoproterenol, dopamine and dobutamine was positive inotropy >> coronary vasodilation > positive chronotropy. Thus, a marked characteristic of colforsin daropate is its potent coronary vasodilator action. On the other hand, each drug significantly increased the adenylate cyclase activity in a dose-related manner: colforsin daropate >> isoproterenol > dopamine = dobutamine. These results suggest that colforsin daropate may be preferable in the treatment of severe heart failure where the coronary blood flow is reduced and beta-adrenoceptor-dependent signal transduction pathway is down-regulated.

PMID: 12499623 [

 

 

 

[top]

 



www.linkstoyou.com This page was done by a student of Bioinformatics, Open University Jerusalem Israel, in a homage to Fermentek and to Dr Berend.
 4mg  noneto biocompare formulae omd ToxicPlants DictCellBio MolBioDict ( test  position )
BioChemical Suppliers
A23187 Actinomycin Aflatoxin Anisomycin Aphidicolin Ascomycin
Bleomycin

Brefeldin

Cerulenin Chromomycin Geldanamycin Cyclopiazonic acid
Cytochalasin Forskolin Fumagillin Fumonisin Hypericin K252a
KT5823 Mitomycin Nigericin Ochratoxin Oligomycin Mycophenolic acid
Paclitaxel Patulin Paxilline Penitrem Puromycin Penicillic acid
Radicicol Rapamycin Staurosporine Sterigmatocystin Thapsigargin Tunicamycin
 Verruculogen  Wortmannin